If a nursing mother can be an ultra-swift metabolizer of codeine, it could lead on to morphine overdose while in the nursing toddler and induce extremely major side effects.

Problems OF USE: The information Within this database is intended to supplement, not substitute for, the experience and judgment of healthcare pros. The data is not really meant to cover all possible utilizes, directions, precautions, drug interactions or adverse effects, nor really should or not it's construed to point that use of a particular drug is Safe and sound, appropriate or productive in your case or any person else.

Pregnancy Checks: Diagnostic pregnancy exams based on immunological reactions between HCG and anti-HCG may perhaps end in Phony-unfavorable or Bogus-good interpretations.

The concomitant usage of Promethazine with Codeine Oral Resolution with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor may lead to decrease codeine amounts, increased norcodeine degrees, and less metabolism by means of 2D6 with resultant lessen morphine levels. This may be connected with a lessen in efficacy, and in certain individuals, may perhaps end in signals and indicators of opioid withdrawal.

Daily life-threatening respiratory depression and Dying have transpired in children who obtained codeine; most circumstances followed tonsillectomy and/or adenoidectomy, and many of the youngsters had proof of becoming an ultra-swift metabolizer of codeine due to a CYP2D6 polymorphism. (five.three) Promethazine with Codeine Oral Resolution is contraindicated in children more youthful than twelve several years of age and in youngsters youthful than eighteen years of age next tonsillectomy and/or adenoidectomy.

We foresee reposting the photographs as soon as we're in a position establish and filter out illustrations or photos that don't match the information provided during the drug labels. NDC Codes

In case you are prescribed this medication on an everyday timetable and skip a dose, take it when you keep in mind. Whether it is close to the time of another dose, skip the skipped dose. Take your future dose in the normal time. Tend not to double the dose to capture up.

Promethazine with Codeine Oral Remedy includes promethazine, a phenothiazine. Phenothiazines are linked to dystonic reactions, specifically in pediatric patients who've an acute disease associated with dehydration.

Lifetime-threatening respiratory melancholy and Demise have occurred in kids who received codeine. Codeine is matter to variability in metabolism dependent upon CYP2D6 genotype (explained underneath), which can result in a heightened exposure to the Lively metabolite morphine. Based upon publish-internet marketing experiences, small children more youthful than twelve yrs old look like much more susceptible to the respiratory depressant outcomes of codeine, significantly if you will discover chance aspects for respiratory despair.

If this SPL contains inactivated NDCs shown because of the FDA initiated compliance action, they will be specified therefore.

A most likely fatal symptom sophisticated occasionally referred to as Neuroleptic Malignant Syndrome (NMS) has become claimed in association with promethazine HCl by itself or in combination with antipsychotic prescription drugs.

This medication may possibly make you much more sensitive to the sun. Limit your time and energy inside the Sunlight. Stay away from tanning booths and sunlamps. Use sunscreen and use protecting clothes when outdoors. Tell your medical professional straight away if you obtain sunburned or have skin blisters/redness.

Making use of this medication with any of the next could cause an increased chance of selected Unwanted side effects but might Promethazine codeine syrup be unavoidable sometimes. If employed together, your physician may well alter the dose or how frequently you use this medication, or Offer you Particular Guidance about the use of food, alcohol, or tobacco.

Employing Alcoholic beverages or tobacco with sure medicines may additionally induce interactions to take place. The following interactions have been selected on The idea in their likely importance and so are not automatically all-inclusive.